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Table 1 The baseline characteristics of rhesus macaques

From: Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model

Group

  

Normal (n=3)

   

DN+NS (n=4)

      

DN+MSCs (n=8)

    

ID

05145

09388

10475

Mean (± s.e.m.)

05593

05265

06145

09475

Mean (± s.e.m.)

04053

05539

06431

07343

09011

10091

10053

10207

Mean (± s.e.m.)

Gender

Male

Male

Male

 

Male

Male

Male

Male

 

Male

Male

Male

Male

Male

Male

Male

Male

 

Body weight (Kg)

4.5

4.9

4.7

4.7±0.2

5

5.1

4.9

5

5±0.08

4.7

5.1

5.3

4.6

4.9

4.7

4.8

4.4

4.81±0.29

CREA (μmol/L)

46.9

62.6

49.4

52.97±8.43

101

113.4

122.9

105.7

110.75±9.58 *

89.2

90.6

84.7

107.8

115.1

97.9

99.1

109.2

99.2±10.77 *

BUN (mmol/L)

4.74

5.17

4.23

4.71±0.47

12.19

9.43

12.27

15.42

12.33±2.45 *

8.66

10.92

9.28

12.4

8.86

11.5

10.1

10.37

10.26±1.31 *

Uric Acid (μmol/L)

1

1

1

1

2

5

3

1

2.75±1.71

3

4

4

3

4

4

3

3

3.5±0.53 *

LDL-C (mmol/L)

1.55

1.72

1.51

1.59±0.11

3.76

5.18

2.11

3.33

3.56±1.27

2.48

2.1

3.74

6.01

5.04

4.92

3.17

3.2

3.83±1.37 *

HDL-C (mmol/L)

2.34

1.85

2.04

2.07±0.25

1.66

2.12

1.21

1.82

1.7±0.38

1.07

1.48

1.71

2.5

1.87

2.04

1.59

1.95

1.78±0.42

CHOL (mmol/l)

3.63

3.75

3.48

3.62±0.14

6.64

8.13

3.73

4.76

5.82±1.96

4.97

3.4

4.9

8.17

6.88

7.76

5.24

5.05

5.8±1.64

Triglycerides (mmol/L)

0.57

0.4

0.6

0.52±0.11

0.66

2.75

0.85

1.25

1.38±0.95 *

0.81

1.56

0.44

1.99

1.63

1.44

1.03

1.5

1.3±0.5 *

FBG (mmol/L)

6.3

5.9

5.8

6±0.26

19.71

19.51

18.04

20.22

19.37±0.94 *

18.86

20.08

17.45

19.92

20.43

18.75

19.43

19.36

19.29±0.94 *

HbA1c (%)

5.7

6

5.9

5.86±0.15

11.5

10.7

10.8

11

11±0.36 *

9.5

10.2

9.3

10.3

8.4

11.5

11

10.4

10.08±0.99 *

Daily insulin (U)

0

0

0

0

1.5

1.2

1

1.5

1.3±0.25 *

1

1.2

1

1.5

1.2

1

1.5

1.2

1.2±0.21 *

Urinary microalbumin (mg/L)

0.03

0.75

1.21

0.75±0.45

11.3

10.9

16.2

12.8

12.8±2.41 *

21.5

23

20.72

17.82

13.2

9.59

12.7

10.9

16.18±5.22 *

Urinary creatinine (μmol/L)

1451

1352

1596

1466.33±122.72

1729

1525

2067

1994

1828.75±249.2

1427

1904

2414

2621

1081

1100

1025

989

1570.13±659.39

Glomerulosclerosis (score)

0

0

0

0

2

2

2

2

2±0 *

2

2

2

2

2

2

2

2

2±0 *

Mesangial matrix deposition (score)

0

0

0

0

1

2

1

2

1±0.59 *

1

2

2

1

2

2

1

2

1.63±0.52 *

Tubular dilation (score)

0

0

0

0

2

3

2

2

2.25±0.5 *

2

3

2

3

3

3

3

3

2.75±0.46 *

Interstitial fibrosis (score)

0

0

0

0

2

2

2

1

1.75±0.5 *

2

1

2

2

2

2

2

2

1.88±0.35 *

  1. CREA serum creatinine, BUN blood urea nitrogen, LDL-C low-density lipoprotein, HDL-C high-density lipoprotein, CHOL cholesterol, FBG fasting blood glucose, HbA1c glycosylated hemoglobin. Score of renal histological changes: 0 = no change, 1 = mild changes, 2 = moderate changes, and 3 = severe changes
  2. *p < 0.05: DN+NS vs. Normal, DN+MSCs vs. Normal
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Stem Cell Research & Therapy

ISSN: 1757-6512