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Table 1 The baseline characteristics of rhesus macaques

From: Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model

Group  Normal (n=3)   DN+NS (n=4)      DN+MSCs (n=8)    
ID051450938810475Mean (± s.e.m.)05593052650614509475Mean (± s.e.m.)0405305539064310734309011100911005310207Mean (± s.e.m.)
GenderMaleMaleMale MaleMaleMaleMale MaleMaleMaleMaleMaleMaleMaleMale 
Body weight (Kg)4.54.94.74.7±0.255.14.955±0.084.75.15.34.64.94.74.84.44.81±0.29
CREA (μmol/L)46.962.649.452.97±8.43101113.4122.9105.7110.75±9.58 *89.290.684.7107.8115.197.999.1109.299.2±10.77 *
BUN (mmol/L)4.745.174.234.71±0.4712.199.4312.2715.4212.33±2.45 *8.6610.929.2812.48.8611.510.110.3710.26±1.31 *
Uric Acid (μmol/L)111125312.75±1.71344344333.5±0.53 *
LDL-C (mmol/L)1.551.721.511.59±0.113.765.182.113.333.56±1.272.482.13.746.015.044.923.173.23.83±1.37 *
HDL-C (mmol/L)2.341.852.042.07±0.251.662.121.211.821.7±0.381.071.481.712.51.872.041.591.951.78±0.42
CHOL (mmol/l)3.633.753.483.62±0.146.648.133.734.765.82±1.964.973.44.98.176.887.765.245.055.8±1.64
Triglycerides (mmol/L)0.570.40.60.52±0.110.662.750.851.251.38±0.95 *0.811.560.441.991.631.441.031.51.3±0.5 *
FBG (mmol/L)6.35.95.86±0.2619.7119.5118.0420.2219.37±0.94 *18.8620.0817.4519.9220.4318.7519.4319.3619.29±0.94 *
HbA1c (%)5.765.95.86±0.1511.510.710.81111±0.36 *9.510.29.310.38.411.51110.410.08±0.99 *
Daily insulin (U)00001.51.211.51.3±0.25 *11.211.51.211.51.21.2±0.21 *
Urinary microalbumin (mg/L)0.030.751.210.75±0.4511.310.916.212.812.8±2.41 *21.52320.7217.8213.29.5912.710.916.18±5.22 *
Urinary creatinine (μmol/L)1451135215961466.33±122.7217291525206719941828.75±249.214271904241426211081110010259891570.13±659.39
Glomerulosclerosis (score)000022222±0 *222222222±0 *
Mesangial matrix deposition (score)000012121±0.59 *122122121.63±0.52 *
Tubular dilation (score)000023222.25±0.5 *232333332.75±0.46 *
Interstitial fibrosis (score)000022211.75±0.5 *212222221.88±0.35 *
  1. CREA serum creatinine, BUN blood urea nitrogen, LDL-C low-density lipoprotein, HDL-C high-density lipoprotein, CHOL cholesterol, FBG fasting blood glucose, HbA1c glycosylated hemoglobin. Score of renal histological changes: 0 = no change, 1 = mild changes, 2 = moderate changes, and 3 = severe changes
  2. *p < 0.05: DN+NS vs. Normal, DN+MSCs vs. Normal