Fig. 2

Multivariate statistical analysis based on metabolomic profiling data to compare FLS cells with iPSCs derived from OA and RA patients. PLS-DA scores plot of a positive mode and b negative mode. c–v Significantly altered metabolites were shown in both groups when reprogramming FLS to iPSC. Data presented mean ± SEM. All data was analyzed by Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001