Fig. 6

Analysis of differential gene expression in the skin from mice treated with hADSCs (M-hADSC) or SVF (M-SVF) compared to untreated skin (M-CON). a Venn diagram displaying the numbers and the overlap of the identified differentially expressed genes in M-hASC vs M-CON (red) and M-SVF vs M-CON (green). b Significantly enriched KEGG pathways. As shown in the bubble diagram, the X-axis represents the enrichment score of the gene sets, the Y-axis shows gene set names, and the size of the bubble indicates the number of genes in that gene set. KEGG pathways with P < 0.05 are significantly enriched. The top 20 significantly different KEGG terms are shown. c Expanded view of the network imported from Cytoscape, where nodes represent core differentially expressed genes in the gene set KEGG “cytokine-cytokine receptor interaction” pathway and edges the interaction. Node size represents “betweenness centrality,” node color represents “degree.” d Heat map of core differentially expressed genes in the gene set KEGG “cytokine-cytokine receptor interaction” pathway with Cytoscape network analysis. The colors in the heat map represent gene expression level (log10(TPM+1)). Red represents higher expression; blue represents lower expression. The brackets represent cluster analysis