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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells

Fig. 1

High concentration of silicate affected morphologic changes and cell viability of BMSCs. a Morphologic changes (× 40) of BMSCs after treatment with different concentrations of sodium metasilicate (0, 0.1, 1.5, and 5 mM). As silicate concentrations increased, the number of suspended and deactivated cells increased. b CCK-8 was applied to detect cell viability (n = 6) after treatment with different concentrations (0, 0.1, 0.5, 1.5, 3, 5 mM) of silicate. Cell viability decreased significantly in groups treated with greater than 1.5 mM silicate compared with that in the control group. c Intracellular silicon concentration increased with extracellular concentration (n = 4). (*p < 0.05, **p < 0.01, ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512