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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Microtubule destabilization caused by silicate via HDAC6 activation contributes to autophagic dysfunction in bone mesenchymal stem cells

Fig. 2

Autophagosomes accumulated in high concentration of silicate-treated BMSCs. a, b Western blot showed the expression of LC3-II and p62 protein after silicate exposure for 24 h (n = 4). LC3-II and p62 simultaneously increased significantly in groups treated with more than 1.5 mM silicate as compared with that in the control group. c, d Autophagosomes were largely accumulated in BMSCs treated with greater than 1.5 mM silicate from LC3 fluorescence (n = 3, 10 random fields per sample). (**p < 0.01, ***p < 0.001)

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Stem Cell Research & Therapy

ISSN: 1757-6512