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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway

Fig. 6

The mechanism of AML cell-secreted exosomal miR-4532 in hematopoiesis of HSCs. AML cell-secreted exosomes transfer miR-4532 into HSCs, and miR-4532 targets and downregulates LDOC1, thus activating the STAT3 signaling pathway. The activation of the STAT3 signaling pathway increased the hematopoietic suppressor gene DKK1 expression, thus suppressing hematopoiesis of HSCs. miR-4532, microRNA-4532; LDOC1, leucine-zipper downregulated in cancer 1; STAT3, signal transducer and activator of transcription 3

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Stem Cell Research & Therapy

ISSN: 1757-6512