Fig. 4

Liraglutide enhanced SPC, Ang-1, and FGF-10 expression through PKAc/β-catenin pathway. Western blot (a–d): hCMSCs were exposed to LPS from 0 to 30 μg/ml with or without 10 nM liraglutide (a). hCMSCs were exposed to 10 nM liraglutide alone or 20 μM H89 alone or their combination (b–d). TCF-4 siRNA3 had the most obvious blocking effect (e); CHIP assay (f–h): TCF-4 was bound to SPC, Ang-1, and FGF-10 genes promoter in hCMSCs (liraglutide group versus vehicle group, *P < 0.05, **P < 0.01). Data are represented as mean ± SD