The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

Table 2 MiRNAs involved in osteogenesis and adipogenesis of GC-treated MSCs

MiRNAs	Species	In vitro/in vivo study	Expression	Functions	Target genes	Ref(s)
MiR-29a	Human, Rat Rat	In vitro In vivo	Down	Osteogenesis	HDAC4	[90,91,92]
MiR-27a	Human	In vitro	Up	Osteogenesis and inhibition of adipogenesis	RUNX1, SMAD5, SATB2, LRP6, FOXO1	[93]
MiR-22	Human	In vitro	Up	Osteogenesis and inhibition of adipogenesis	SMAD4, SATB2, HDAC6	[93]
MiR-23a	Human	In vitro	Up	Osteogenesis	SATB1, STAT5B, TMEM135, FGF2, NFIB, SMAD5, IHH, RUNX2	[93]
MiR-221	Human	In vitro	Up	Osteogenesis	Wnt1, Sox4	[93]
MiR-26a	Human	In vitro	Up	Osteogenesis	SMAD1, Wnt5α, SMAD4, TMEM135	[93]
MiR-130a	Human	In vitro	Up	Osteogenesis	SMAD5, SMAD4, BMPR1B, BMPR2	[93]
MiR-199a-5p	Human	In vitro	Up	Osteogenesis	TMEM135, Sox4	[93]
MiR-196a	Human	In vitro	Up	Osteogenesis and inhibition of adipogenesis	COL1A1, COL1A2, COL3A1, FOXO1	[93]
MiR-155	Human	In vitro	Up	Osteogenesis	SATB2	[93]
MiR-21	Human	In vitro	Down	Inhibit of osteogenesis	SMAD7, Sox2, TGFBR2	[93]
MiR-140-3p	Human	In vitro	Down	Inhibit of osteogenesis	Acvr2b, CBL, HDAC4	[93]
MiR-214	Human	In vitro	Down	Inhibit of osteogenesis and adipogenesis	CBL, GSK3β	[93]
MiR-744	Human	In vitro	Down	Inhibit of osteogenesis	TGFβ1	[93]
MiR-320a	Human	In vitro	Down	Inhibit of osteogenesis	CBL, BMP3, HDAC4, Sox4, Acvr2b, TGFBR2	[93]
MiR-320b	Human	In vitro	Down	Inhibit of osteogenesis	CBL, BMP3, HDAC4, Sox4, Acvr2b, TGFBR2	[93]
MiR-320c	Human	In vitro	Down	Inhibit of osteogenesis	CBL, BMP3, HDAC4, Sox4, Acvr2b, TGFBR2	[93]
MiR-216a	Human Mice	In vitro In vivo	Up	Osteogenesis	c-Cbl	[94]
MiR-708	Human	In vitro	Up	Inhibition of osteogenesis	SMAD3	[95]

Species, species involved in study; In vitro/in vivo study, study performed in vitro or in vivo; Expression, expression of miRNAs during osteogenic or adipogenic differentiation of GC-treated MSCs: Up, upregulation, Down, downregulation; Functions, functions of miRNAs during osteogenic or adipogenic differentiation of GC-treated MSCs; Target genes, target genes determined or predicted by the study; References, references related to the study in this table

ISSN: 1757-6512