Fig. 3

The effect of IFN-γ and TX or CQ co-treatments on miRNA levels. NanoString panel of human 800 miRNA was used to determine the levels of miRNA in MIAMI cells exposed to treatments indicated on the figure. a Unsupervised hierarchical clustering of 30 miRNAs whose levels changed in all treatment groups as indicated. Only those miRNAs with a statistically significantly different expression (p < 0.05) were used for analysis. Red and green indicate high and low levels of expression, respectively. b Example of treatment-specific expression of miRNAs and their target HLA genes from the dataset. c Example of treatment-specific expression of miRNAs and their target immunomodulatory genes from the dataset. The treatment and associated arrows are indicated