From: Genetically modified mesenchymal stem cell therapy for acute respiratory distress syndrome
Candidate gene | Engineering vector | Animal species | ARDS model | MSC source | MSC species | MSC dose | Administration route | References |
---|---|---|---|---|---|---|---|---|
CXCR4 | Lentiviral vector | Rat | LPS-induced | Bone marrow | Rat | 1 × 106 | Tail vein | [53] |
EP2 | Lentiviral vector | Mice | LPS-induced | Bone marrow | Mice | 5 × 105 | Tail vein | [54] |
sST2 | Lentiviral vector | Mice | LPS-induced | Adipose tissue | Human | 1 × 106 | Tail vein | [60] |
ACE2 | Lentiviral vector | Mice | LPS-induced | Bone marrow | Mice | 5 × 105 | Tail vein | [63] |
KGF | Lentiviral vector | Mice | LPS-induced | Bone marrow | Mice | 5 × 105 | Tail vein | [67] |
HGF | Adenoviral vector | Mice | radiation-induced | Bone marrow | Human | 1 × 106 | Tail vein | [72] |
Ang-1 | Lentiviral vector | Mice | LPS-induced | Bone marrow | Mice | 1 × 105 | Jugular vein | [79] |
Ang-1 | Nuclear-targeting electroporation | Mice | LPS-induced | Bone marrow | Mice | 2.5 × 105 | Jugular vein | [80] |
MnSOD | Lentiviral vector | Mice | radiation-induced | Bone marrow | Human | 1 × 106 | Tail vein | [85] |
HO-1 | Lentiviral vector | Rat | LPS-induced | Bone marrow | Rat | 5 × 105 | Tail vein | [86] |