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Table 2 The summary of stem cell-derived cell sheet transplantation experiments in MI

From: Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction

Cell sources Model Species Cardiac function Wall thickness Neovasculization Fibrosis Trophic factors Reference
Myoblasts (rat) MI Rat Improvement of EF Increased Not mentioned Decreased SDF-1, HGF, VEGF 36
Myoblasts (rat) MI Rat Improvement of EF Increased Increased Decreased SDF-1, HGF,VEGF 37
Myoblasts (porcine) MI Porcine Improvement of EF Not mentioned Increased Decreased No difference 40
Myoblasts (rat) MI Rat Improvement of EF Increased Increased Decreased Not mentioned 55
Myoblasts + Bcl-2 (rat) MI Rat Improvement of EF No difference Increased Decreased VEGF, PLGF 56
Myoblasts + Bcl-2 (rat) MI Rat Improvement of EF Increased Increased Not mentioned Not mentioned 57
Myoblasts + OP (porcine) MI Porcine Improvement of EF Not mentioned Increased Decreased VEGF, STAT3 54
Myoblasts + HGF (rat) MI Rat Improvement of EF No difference Increased Not mentioned No difference 92
Myoblasts + laminin alpha2-secreting fibroblasts (rat) MI Rat Improvement of EF Increased Increased Decreased HGF, IGF-1, VEGF 58
Myoblasts (rat) MI Infant rat Improvement of EF Increased Increased Decreased Not mentioned 40
Myoblasts (porcine) + TPP with an OP MI Porcine Improvement of EF Not mentioned Increased Not mentioned Not mentioned 59
Mesenchymal stem cells (rat adipose tissue) MI Rat Improvement of EF, inhibition of LV dilatation Increased Increased Not mentioned HGF, VEGF 42
Mesenchymal stem cells (rat bone marrow) MI Rat Improvement of EF Not mentioned Increased Decreased Not mentioned 44
Mesenchymal stem cells (human adipose tissue) MI Rat Improvement of EF Not mentioned Not mentioned Not mentioned Not mentioned 43
Mesenchymal stem cells (rabbit bone tissue) + hypoxic preconditioning MI Rabbit Improvement of EF Not mentioned Increased Not mentioned VEGF 45
Mesenchymal stem cells (human menstrual blood) MI Rat Improvement of EF, inhibition of LV dilatation Not mentioned Not mentioned Decreased No difference 46
Adipocyte (mouse adipose tissue) MI Mouse Improvement of EF Not mentioned Not mentioned Decreased Adiponectin 47
ADSC (rat adipose tissue) MI Rat Improvement of EF Not mentioned Increased Not mentioned Not mentioned 67
ADSC (mouse adipose tissue) MI Rat Improvement of EF Increased Increased Decreased Adiponectin, SDF-1, VEGF, IGF-1, bFGF, collagen I, laminin, fibronectin, vimentin 66
Endothelial progenitor cells (rat peripheral blood) MI Rat Improvement of EF Not mentioned Increased Decreased No difference 33
Sca-1(+) cardiac progenitor cells (mouse) MI Mouse Improvement of EF, inhibition of LV dilatation Not mentioned Increased Decreased VCAM-1 48
Muscle-derived stem cells (mouse) MI Mouse Improvement of EF, inhibition of LV dilatation Increased Increased Decreased VEGF 61
Cardiaomyocytes/vascular cells (mouse ES cells) MI Mouse Improvement of EF, inhibition of LV dilatation Increased Increased Not mentioned VEGF 51
Cardiomyocytes/vascular cells + GHMs (mouse ES cells) MI Mouse Improvement of EF Not mentioned Increased Not mentioned Not mentioned 86
Cardiomyocytes (human iPS cells) MI Porcine Improvement of EF, inhibition of LV dilatation Increased Increased Decreased VEGF, bFGF 50
Cardiomyocytes (mouse iPS cells) MI rat Improvement of EF Increased Increased Decreased Not mentioned 72
Cardiomyocytes (human iPS cells) + OF MI Porcine Improvement of EF Not mentioned Increased Not mentioned VEGF, SDF-1, bFGF 73
Cardiomyocytes/vascular cells (human iPS cells) MI Rat Improvement of EF Increased Increased Decreased Not mentioned 75
Cardiomyocytes (human iPS cells) MI Mouse Improvement of EF Not mentioned Increased Not mentioned Not mentioned 76
Cardiomyocytes/vascular cells (human iPS cells) MI Porcine Improvement of EF Increased Increased Decreased Not mentioned 77
Cardiomyocytes (human iPS cells) + OF MI Porcine Improvement of EF Not mentioned Increased Not mentioned VEGF, SDF-1, bFGF 74
  1. MI myocardial infarction, OP omentopexy, HGF hepatocyte growth factor, TPP transphrenic peritoneoscopy, ADSC adipose-derived stromal cell, ES embryonic stem, GHMs gelatin hydrogel microspheres, iPS induced pluripotent stem, OF omental flap, EF ejection fraction, LV left ventricle