Table 2 The summary of stem cell-derived cell sheet transplantation experiments in MI
From: Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction
Cell sources | Model | Species | Cardiac function | Wall thickness | Neovasculization | Fibrosis | Trophic factors | Reference |
|---|---|---|---|---|---|---|---|---|
Myoblasts (rat) | MI | Rat | Improvement of EF | Increased | Not mentioned | Decreased | SDF-1, HGF, VEGF | 36 |
Myoblasts (rat) | MI | Rat | Improvement of EF | Increased | Increased | Decreased | SDF-1, HGF,VEGF | 37 |
Myoblasts (porcine) | MI | Porcine | Improvement of EF | Not mentioned | Increased | Decreased | No difference | 40 |
Myoblasts (rat) | MI | Rat | Improvement of EF | Increased | Increased | Decreased | Not mentioned | 55 |
Myoblasts + Bcl-2 (rat) | MI | Rat | Improvement of EF | No difference | Increased | Decreased | VEGF, PLGF | 56 |
Myoblasts + Bcl-2 (rat) | MI | Rat | Improvement of EF | Increased | Increased | Not mentioned | Not mentioned | 57 |
Myoblasts + OP (porcine) | MI | Porcine | Improvement of EF | Not mentioned | Increased | Decreased | VEGF, STAT3 | 54 |
Myoblasts + HGF (rat) | MI | Rat | Improvement of EF | No difference | Increased | Not mentioned | No difference | 92 |
Myoblasts + laminin alpha2-secreting fibroblasts (rat) | MI | Rat | Improvement of EF | Increased | Increased | Decreased | HGF, IGF-1, VEGF | 58 |
Myoblasts (rat) | MI | Infant rat | Improvement of EF | Increased | Increased | Decreased | Not mentioned | 40 |
Myoblasts (porcine) + TPP with an OP | MI | Porcine | Improvement of EF | Not mentioned | Increased | Not mentioned | Not mentioned | 59 |
Mesenchymal stem cells (rat adipose tissue) | MI | Rat | Improvement of EF, inhibition of LV dilatation | Increased | Increased | Not mentioned | HGF, VEGF | 42 |
Mesenchymal stem cells (rat bone marrow) | MI | Rat | Improvement of EF | Not mentioned | Increased | Decreased | Not mentioned | 44 |
Mesenchymal stem cells (human adipose tissue) | MI | Rat | Improvement of EF | Not mentioned | Not mentioned | Not mentioned | Not mentioned | 43 |
Mesenchymal stem cells (rabbit bone tissue) + hypoxic preconditioning | MI | Rabbit | Improvement of EF | Not mentioned | Increased | Not mentioned | VEGF | 45 |
Mesenchymal stem cells (human menstrual blood) | MI | Rat | Improvement of EF, inhibition of LV dilatation | Not mentioned | Not mentioned | Decreased | No difference | 46 |
Adipocyte (mouse adipose tissue) | MI | Mouse | Improvement of EF | Not mentioned | Not mentioned | Decreased | Adiponectin | 47 |
ADSC (rat adipose tissue) | MI | Rat | Improvement of EF | Not mentioned | Increased | Not mentioned | Not mentioned | 67 |
ADSC (mouse adipose tissue) | MI | Rat | Improvement of EF | Increased | Increased | Decreased | Adiponectin, SDF-1, VEGF, IGF-1, bFGF, collagen I, laminin, fibronectin, vimentin | 66 |
Endothelial progenitor cells (rat peripheral blood) | MI | Rat | Improvement of EF | Not mentioned | Increased | Decreased | No difference | 33 |
Sca-1(+) cardiac progenitor cells (mouse) | MI | Mouse | Improvement of EF, inhibition of LV dilatation | Not mentioned | Increased | Decreased | VCAM-1 | 48 |
Muscle-derived stem cells (mouse) | MI | Mouse | Improvement of EF, inhibition of LV dilatation | Increased | Increased | Decreased | VEGF | 61 |
Cardiaomyocytes/vascular cells (mouse ES cells) | MI | Mouse | Improvement of EF, inhibition of LV dilatation | Increased | Increased | Not mentioned | VEGF | 51 |
Cardiomyocytes/vascular cells + GHMs (mouse ES cells) | MI | Mouse | Improvement of EF | Not mentioned | Increased | Not mentioned | Not mentioned | 86 |
Cardiomyocytes (human iPS cells) | MI | Porcine | Improvement of EF, inhibition of LV dilatation | Increased | Increased | Decreased | VEGF, bFGF | 50 |
Cardiomyocytes (mouse iPS cells) | MI | rat | Improvement of EF | Increased | Increased | Decreased | Not mentioned | 72 |
Cardiomyocytes (human iPS cells) + OF | MI | Porcine | Improvement of EF | Not mentioned | Increased | Not mentioned | VEGF, SDF-1, bFGF | 73 |
Cardiomyocytes/vascular cells (human iPS cells) | MI | Rat | Improvement of EF | Increased | Increased | Decreased | Not mentioned | 75 |
Cardiomyocytes (human iPS cells) | MI | Mouse | Improvement of EF | Not mentioned | Increased | Not mentioned | Not mentioned | 76 |
Cardiomyocytes/vascular cells (human iPS cells) | MI | Porcine | Improvement of EF | Increased | Increased | Decreased | Not mentioned | 77 |
Cardiomyocytes (human iPS cells) + OF | MI | Porcine | Improvement of EF | Not mentioned | Increased | Not mentioned | VEGF, SDF-1, bFGF | 74 |