Fig. 2

The proliferation and apoptosis of GCs in different condition. The statistical charts of GCs viability co-cultured with UCMSCs transfected with the plasmids of HO-1/shHO-1 for 12 h (a-1), 24 h (a-2), 48 h (a-3), or 72 h (a-4). The tendency charts of GC proliferation administrated with anisomycin (0–20 μM) (a-5) or SP600125 (0–20 μM) for 12–72 h (a-6). The statistical charts of GCs’ apoptosis co-cultured with UCMSCs transfected with the plasmids of HO-1/shHO-1 for 12 h (b-1), 24 h (b-2), 48 h (b-3), or 72 h (b-4). The tendency charts of GC apoptosis administrated with anisomycin (0–20 μM) (b-5), or treated with SP600125 (0–20 μM) for 12–72 h (b-6). Data presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs DMSO group, GC group, or NC group, separately. DMSO, dimethylsulfoxide; GCs, granulosa cells; HO-1, heme oxygenase-1; NC, empty vector; UCMSCs, umbilical cord mesenchymal stem cells