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Table 2 Meta-analysis of the efficacy of MSC in the therapy of lupus nephritis

From: Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

Indicators Studies Q test Model OR/WMD p
Number p value selected (95%CI)
ds-DNA 24 < 0.00001 Random − 29.58 (−41.18, − 17.99) < 0.00001
ANA 4 < 0.00001 Random − 70.93 (−104.55, − 37.32) < 0.0001
Scr 8 < 0.00001 Random − 8.20 (−12.71, − 3.69) 0.0004
BUN 7 < 0.00001 Random − 14.57 (−20.50, − 8.64) < 0.00001
Albumin 2 0.10 Random 7.22 (3.74, 10.69) < 0.0001
Proteinuria 21 < 0.00001 Random − 4.26 (−5.15, − 3.37) < 0.00001
IgM 3 < 0.00001 Random − 4437.90 (− 12,581.07, 3705.28) 0.29
IL-2 4 < 0.00001 Random − 50.86 (− 78.76, − 22.96) 0.0004
IL-4 2 < 0.0001 Random − 92.42 (− 332.33, 147.49) 0.45
IL-6 7 < 0.00001 Random − 33.55 (− 83.31, 16.21) 0.19
IL-10 6 < 0.00001 Random − 29.67 (− 68.25, 8.91) 0.13
IL-12 3 < 0.00001 Random − 328.24 (− 652.20, − 4.29) 0.05
IL-17 5 < 0.00001 Random − 36.40 (− 65.88, − 6.93) 0.02
TGF-β 3 < 0.00001 Random − 0.09 (− 2.90, 2.72) 0.95
MCP-1 2 < 0.00001 Random − 5917.71 (− 17,303.66, 5468.23) 0.31
IFN-γ 4 < 0.00001 Random − 240.24 (−364.73, − 115.75) 0.0002
TNF-α 6 < 0.00001 Random − 74.71 (− 167.69, 18.28) 0.12
Th1 3 < 0.00001 Random − 6.37 (− 13.12, 0.37) 0.06
Th17 4 < 0.00001 Random − 0.15 (− 0.57, 0.27) 0.48
Foxp3 2 0.09 Random 1.21 (− 0.58, 3.01) 0.19
Treg 3 < 0.00001 Random 4.73 (− 1.51, 10.97) 0.14
Renal sclerosis score 10 < 0.00001 Random − 1.92 (− 2.66, − 1.18) < 0.00001