Skip to main content

Table 2 Meta-analysis of the efficacy of MSC in the therapy of lupus nephritis

From: Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

IndicatorsStudiesQ testModelOR/WMDp
Numberp valueselected(95%CI)
ds-DNA24< 0.00001Random− 29.58 (−41.18, − 17.99)< 0.00001
ANA4< 0.00001Random− 70.93 (−104.55, − 37.32)< 0.0001
Scr8< 0.00001Random− 8.20 (−12.71, − 3.69)0.0004
BUN7< 0.00001Random− 14.57 (−20.50, − 8.64)< 0.00001
Albumin20.10Random7.22 (3.74, 10.69)< 0.0001
Proteinuria21< 0.00001Random− 4.26 (−5.15, − 3.37)< 0.00001
IgM3< 0.00001Random− 4437.90 (− 12,581.07, 3705.28)0.29
IL-24< 0.00001Random− 50.86 (− 78.76, − 22.96)0.0004
IL-42< 0.0001Random− 92.42 (− 332.33, 147.49)0.45
IL-67< 0.00001Random− 33.55 (− 83.31, 16.21)0.19
IL-106< 0.00001Random− 29.67 (− 68.25, 8.91)0.13
IL-123< 0.00001Random− 328.24 (− 652.20, − 4.29)0.05
IL-175< 0.00001Random− 36.40 (− 65.88, − 6.93)0.02
TGF-β3< 0.00001Random− 0.09 (− 2.90, 2.72)0.95
MCP-12< 0.00001Random− 5917.71 (− 17,303.66, 5468.23)0.31
IFN-γ4< 0.00001Random− 240.24 (−364.73, − 115.75)0.0002
TNF-α6< 0.00001Random− 74.71 (− 167.69, 18.28)0.12
Th13< 0.00001Random− 6.37 (− 13.12, 0.37)0.06
Th174< 0.00001Random− 0.15 (− 0.57, 0.27)0.48
Foxp320.09Random1.21 (− 0.58, 3.01)0.19
Treg3< 0.00001Random4.73 (− 1.51, 10.97)0.14
Renal sclerosis score10< 0.00001Random− 1.92 (− 2.66, − 1.18)< 0.00001