Table 2 The five most-enriched GO categories and KEGG pathways for the target genes of conserved and high sperm miRNAs (P < 0.05, FDR < 0.05)
ID | Term | Count | P value | FDR |
|---|---|---|---|---|
Biological process | ||||
 GO:0006351 | Transcription, DNA-templated | 254 | 2.65E−20 | 4.99E−17 |
 GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 155 | 7.38E−18 | 1.39E−14 |
 GO:0006355 | Regulation of transcription, DNA-templated | 283 | 1.17E−17 | 2.21E−14 |
 GO:0045893 | Positive regulation of transcription, DNA-templated | 95 | 1.89E−12 | 3.56E−09 |
 GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | 111 | 4.19E−12 | 7.88E−09 |
Cellular component | ||||
 GO:0005737 | Cytoplasm | 668 | 1.71E−22 | 2.56E−19 |
 GO:0016020 | Membrane | 634 | 4.87E−10 | 7.31E−07 |
 GO:0005634 | Nucleus | 588 | 1.92E−15 | 2.83E−12 |
 GO:0005654 | Nucleoplasm | 208 | 4.08E−08 | 6.12E−05 |
 GO:0005829 | Cytosol | 194 | 5.85E−08 | 8.78E−05 |
Molecular function | ||||
 GO:0005515 | Protein binding | 473 | 8.29E−24 | 1.34E−20 |
 GO:0046872 | Metal ion binding | 353 | 9.70E−11 | 1.57E−07 |
 GO:0003677 | DNA binding | 227 | 5.16E−13 | 8.37E−10 |
 GO:0000166 | Nucleotide binding | 198 | 2.71E−05 | 0.043909 |
 GO:0016740 | Transferase activity | 161 | 4.83E−06 | 0.007827 |
KEGG pathway | ||||
 mmu04151 | PI3K-Akt signaling pathway | 58 | 3.05E−08 | 3.97E-05 |
 mmu04010 | MAPK signaling pathway | 46 | 4.87E−08 | 6.34E−05 |
 mmu04810 | Regulation of actin cytoskeleton | 38 | 1.74E−06 | 0.002264 |
 mmu04152 | AMPK signaling pathway | 27 | 3.35E−06 | 0.004361 |
 mmu04550 | Signaling pathways regulating pluripotency of stem cells | 27 | 1.40E−05 | 0.018295 |