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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts

Fig. 4

Quantitative polymerase chain reaction (qPCR) quantification of human mitochondrial DNA confirms the presence of human cells within rat hearts but not other organs 4 weeks after cell transplantation. a Plot of SYBR-based human mitochondrial DNA quantification demonstrated human cell distribution in each organ of rats in the CTL group. b Plot of SYBR-based human mitochondrial DNA quantification demonstrated human cell distribution in each organ of the iPS-CM group. Cardiomyocytes were used as a positive control. c qPCR quantification analysis of human mitochondria DNA demonstrated that human cells survived in rat hearts but not in other organs in the iPS-CM group (vs control group at 4 weeks following iPSC-CM transplantation) (n = 3 per group). CTL control, iPSC-CMs induced pluripotent stem cell-derived cardiomyocytes. Unpaired two-tailed t-test with * vs CTL P < 0.05, *** vs CTL P < 0.005, n.s. = not significant

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Stem Cell Research & Therapy

ISSN: 1757-6512