Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Fig. 4

The effects of miRNAs in MSC exosomes on beta cells. a The miRNAs in MSC-derived exosomes were detected by Illumina HiSeq. MSC exosomes contained abundant miRNAs. MiR-21, let-7 g, miR-1246, miR-381, and miR-100 were the most abundant miRNAs in MSC exosomes. b The effect of the mimics (100 nM for each mimic) of the five most abundant miRNAs on beta cell survival in hypoxia. c The effect of the inhibitors (100 nM for each inhibitor) of the five most abundant miRNAs and their control miRNAs on beta cell survival in hypoxia. d Dose-dependent effects of miR-21 on beta cells in hypoxia. Cell viability was assayed by the CCK-8 method. OD values were detected at a wavelength of 450 nm. The results are representative of three independent experiments. Data are expressed as the mean ± SD. *P < 0.05, compared with the mimic control group

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512