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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

Fig. 6

Diagram of the proposed model of MSC exosomes protecting beta cells against hypoxia-induced apoptosis. Hypoxia induces beta cell apoptosis by activating ER stress and p38 MAPK signalling and then upregulates the apoptosis-related proteins caspase 3 and parp, reducing survivin protein expression. MSCs could protect beta cells against apoptosis through exosomes carrying miR-21, which could alleviate hypoxia-mediated ER stress and inhibit hypoxia-induced p38 MAPK phosphorylation

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Stem Cell Research & Therapy

ISSN: 1757-6512