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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Mesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro

Fig. 2

The modulatory effect of HGF secreted by MSCs on Th17/Treg cell differentiation in CD4+ T cells analysed by flow cytometry. The results showed that the percentage of CD4+CD25+Foxp3+ cells was significantly increased in the CD4+ T cell population, but the MSC-induced effect was significantly inhibited by an anti-HGF antibody (p < 0.05, a, c). The percentage of CD4+CD3+RORrt+ cells was significantly decreased after MSC coculture. However, the MSC-induced effect was significantly inhibited by the anti-HGF antibody (p < 0.05, b, d) (n = 3; *p < 0.05 or **p < 0.01 vs. the CD4+ group; #p < 0.05 vs. the MSC+CD4+ group). MSCs, mesenchymal stem cells; rmHGF, recombinant mouse hepatocyte growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512