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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Fig. 1

aGVHD MSCs showed impaired self-renewal capacity. a Serial CUF-F experiments and b secondary sphere formation experiments were performed. Bar in Fig. 3a upper row represents 5 mm. Bar in a lower row represent 200 μm. c The number of CFU-Fs and d cell spheres in aGVHD group was remarkably decreased relative to their counterparts in non-aGVHD group. *p < 0.05, **p < 0.01, n = 5. e mRNA expression and f protein level of Oct-4 and Sox-2 were lower in aGVHD MSCs. *p < 0.05, **p < 0.01, compared with that of non-aGVHD MSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512