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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Fig. 2

aGVHD MSCs showed impaired osteogenic and adipogenic differentiation. a The osteoblastogenesis and mineralization of MSCs were determined by ALP staining and von Kossa respectively. The adipogenesis of MSCs were showed by Oil-Red-O staining. The aGVHD MSCs exhibited decreased osteogenic and adipogenic activities. Bars in a represent 200 μm. b The mRNA expression of genes (Runx-2 and Osteorix) that control MSC osteogenic differentiation and genes (CEBP/α and PPARγ) that control MSC adipogenic differentiation were decreased in aGVHD MSCs relative to their counterparts in non-aGVHD MSCs. *p < 0.05, **p < 0.01, n = 5

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Stem Cell Research & Therapy

ISSN: 1757-6512