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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Tumor necrosis factor α in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity

Fig. 5

TNF-α in aGVHD BM supernatants suppressed the multi-differentiation of MSCs. a The addition of anti-TNF-α neutralization antibody rescued the ALP activities and mineralization as well as fat droplet development in MSCs. Bars in a represent 200 μm. b The TNF-α neutralization antibody rescued the expression of osteogenic genes Runx2 and Osteorix and the adipogenic genes CEBP/α and PPARγ. *p < 0.05, compared with aGVHD groups, n = 5

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Stem Cell Research & Therapy

ISSN: 1757-6512