Fig. 8
Efficacy of hWJ-MSC in mouse skin wound closure. a Gross view of mouse excisional wound splinting model after transplantations of control vehicle medium (sham), PBS, hucMSC-CM, hucMSC-dp-Ex, hucMSC-Ex, or hucMSC at day 0, days 7, and day 14. b H&E staining of wound sections treated with PBS, hucMSC-CM, hucMSC-dp-Ex, hucMSC-Ex, and hucMSC at days 7 and 14 after the operation. N, normal region; W, wound region. Scale bar = 200 μm. c Wound measurement in each mouse group; n = 6 per group. *P < 0.05 for treatment with hucMSC-CM, hucMSC-Ex, and hucMSC vs. PBS; *P > 0.05 for sham and hucMSC-dp-Ex vs. PBS at days 7 and 14. d Proportion of histological wound healing; n = 6 per group. *P < 0.05 for treatment with hucMSC-CM, hucMSC-Ex, and hucMSC vs. PBS; *P > 0.05 for sham and hucMSC-dp-Ex vs. PBS at days 7 and 14