Fig. 4

MSC-MVs attenuate the BLM-induced apoptosis and inflammation via elevating autophagy. The protein levels of autophagy-related LC3-I, LC3-II, and Beclin-1 (a); levels of IL-6, IL-8, and TNF-α in cell supernatant (b); and annexin V-FITC/PI apoptotic assay (c) in L2 cells in the groups of BLM, BLM+MVs, BLM+MVs+DMSO, and BLM+MVs+MHY1485. Data are presented as the means ± SD (n = 3). **p < 0.01, vs. BLM; ^##p < 0.01, vs. BLM+MVs+DMSO