Table 2 Summary of Patients data, and Results for Vocal Fold function parameters, Pressure data and Patient’s subjective ratings preoperative and after at 1 year
Patient | Group (vocal fold damage) | Treatment: MSC or MSC+hyaluronan (HA) (unilateral or bilateral) | Side effects: SAE (systemic reaction, airway problem, infection); minor (e.g., fold edema, laryngitis) | Age, sex | Voice Handicap Index (pre/postop 0–120) (*VHI change ≥ 13 points decrease = sign. Improvement) | Vocal fold vibration qualitative ratings (pre/postop): mucosal wave, vibration amplitude, glottal closure | Vocal fold vibration, computerized analysis (pre/postop) (normalized U) | Phonation pressure threshold: PTP (cm H2O) (pre/postop) **decrease ≥ 0.5 cm = positive change |
|---|---|---|---|---|---|---|---|---|
Max. area variations (increase = positive), glottal closure (decrease = positive), open/closed coefficient (%) (decrease = positive) | ||||||||
1 | Scar+defect (uni) | MSC, uni | None | 66, male | 53/24* | Improved | 1732/2146, 49/0, 78/68, improved | 5.5/4.7** |
2 | Severe scar (bilat) | MSC, bilat | None | 53, male | 86/53* | Improved | – | 7.8/4.1** |
3 | Sulcus+scar (bilat) | MSC, uni | None | 57, female | 78/74 | Decreased, Gl. closure improved | 1723/2021, 107/40, 82/71, improved | 6.4/4.0** |
4 | Scar+defect (uni) | MSC, uni | None | 50, male | 65/74 | Improved | 1432/2124, 76/84, 68/74, unchanged | 4.0/2.7** |
5 | Scar (bilat) | MSC, bilat | None | 71, male | 93/61* | Improved | 1290/1476, 0/0, 75/59, improved | 4.3/2.8** |
6 | Scar (uni) large defect | MSC+HA, uni | None | 55, male | 103/104 | Improved | – | 5.4/5.5 |
7 | Scar (uni) large defect | MSC+HA, uni | None | 70, male | 59/69 | Improved | 633/1357, 139/11, 64/78, improved | 4.9/5.0 |
8 | Scar (uni) large defect | MSC+HA, uni | None | 58, male | 80/87 | Unchanged | 1498/3278, 209/540, −, unchanged | 4.8/4.4 |
9 | Scar severe (bilat) | MSC, bilat | None | 74, male | 89/85 | Decreased | –, 740/1262,–, decreased | 8.3/3.5** |
10 | Scar (uni) large defect | MSC, uni | None | 48, female | 109/72* | Decreased, Gl. closure improved | 1517/2692, 942/553, 58/50, improved | 5.7/4.7** |
11 | Sulcus+scar bilat | MSC+HA, uni | None | 42, female | 105/51* | Unchanged | 2430/3249, 0/0, 88/37, improved | 6.6/5.8** |
12 | Sulcus+scar (bilat) | MSC+HA, uni | None | 45, female | 113/92* | Improved | 1761/1973, 2/0, 79/65, improved | 5.9/5.6 |
13 | Sulcus+scar bilat | MSC+HA, uni | None | 51, male | 74/82 | Decreased | 3602/4691, 3/59, 76/77, unchanged | 6.0/5.3** |
14 | Scar (uni) large defect | MSC+HA, uni | None | 48, female | 85/35* | Improved | 566/1716, 0/0, 51/47, improved | 6.5/4.4 ** |
15 | Sulcus+scar (bilat) | MSC, uni | None | 43, male | 50/13* | Improved | 931/1579, 50/0, 75/81, improved | 5.7/4.3** |
16 | Sulcus+scar (bilat) | MSC+HA, uni | None | 30, male | 86/87 | Improved | 1216/1210, 439/19, 93/81, improved | 8.4/7.6** |