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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Loss of receptor tyrosine kinase-like orphan receptor 2 impairs the osteogenesis of mBMSCs by inhibiting signal transducer and activator of transcription 3

Fig. 3

Reduced expression of osteogenic markers in neonatal Ror2 CKO mice (P0) compared with the littermate control (Con). a Immunohistofluorescence staining of ulna proximal epiphysis showed that less OSX, OPN, COLlA1, and Sox9 were found in Ror2 CKO samples. Scale bar = 250 μm. b RNAs were extracted from ulna proximal epiphysis. Quantitative real-time PCR revealed a significant decrease of mRNA expression of OCN, OPN, and COLlA1 in Ror2 CKO compared with controls (n = 3, *P < 0.05 vs. Con)

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Stem Cell Research & Therapy

ISSN: 1757-6512