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Table 1 Upregulated genes in Epi-SCs induced by SKPs

From: PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration

Gene

Description

Log2(FC)

Fold change

Fgf21

Fibroblast growth factor 21

12.22

4780

Il6

Interleukin 6

9.76

870

Lamc3

Laminin gamma 3

4.99

31.71

Tnn

Tenascin N

4.28

19.37

Pgf

Placental growth factor

4.14

17.67

Thbs4

Thrombospondin 4

3.97

15.63

Csf3

Colony-stimulating factor 3 (granulocyte)

3.76

13.51

Ngf

Nerve growth factor

3.67

12.73

Col1a1

Collagen, type I, alpha 1

3.65

12.51

Osm

Oncostatin M

3.26

9.6

Col6a2

Collagen, type VI, alpha 2

3.05

8.28

Tlr2

Toll-like receptor 2

2.94

7.67

Fn1

Fibronectin 1

2.91

7.50

Vegfc

Vascular endothelial growth factor C

2.78

6.86

Lama4

Laminin, alpha 4

2.42

5.36

Fgf16

Fibroblast growth factor 16

2.39

5.25

Lamc2

Laminin, gamma 2

2.31

4.97

Col1a2

Collagen, type I, alpha 2

2.26

4.77

Col6a3

Collagen, type VI, alpha 3

2.24

4.73

Col6a1

Collagen, type VI, alpha 1

2.23

4.69

Tnc

Tenascin C

2.21

4.62

Vegfa

Vascular endothelial growth factor A

2.10

4.30

Lama2

Laminin, alpha 2

1.89

3.72

Ifnar2

Interferon (alpha and beta) receptor 2

1.72

3.30

Spp1

Secreted phosphoprotein 1

1.66

3.16

Efna1

Ephrin A1

1.56

2.94

Lamb3

Laminin, beta 3

1.52

2.87

Csf1

Colony stimulating factor 1 (macrophage)

1.31

2.48

Lama1

Laminin, alpha 1

3.76

13.51

Col4a1

Collagen, type IV, alpha 1

1.17

2.25

Fgf7

Fibroblast growth factor 7

1.16

2.24

Lamb1

Laminin B1

1.11

2.15

Lama3

Laminin, alpha 3

1.04

2.06

  1. RNA-Seq revealed upregulated (> 2-fold) genes in the category of secreted proteins in Epi-SCs after being cultured in mixture with SKPs for 24 h
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Stem Cell Research & Therapy

ISSN: 1757-6512