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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway

Fig. 8

Immunohistochemical staining of the sections of representative rat femoral heads. a Representative images of CD31 staining in the control, MPS, and MPS + VO-OHpic groups. b Relative CD31 expression was measured with the ImageJ software. ∗P < 0.05 versus control, #P < 0.05 versus MPS group. Error bar represents SD. c Representative images of VEGF staining in the control, MPS, and MPS + VO-OHpic groups. d Relative VEGF expression was measured with the ImageJ software. ∗P < 0.05 versus control, #P < 0.05 versus MPS group. Error bar represents SD. e Representative images of VEGFR2 staining in the control, MPS, and MPS + VO-OHpic groups. f Relative VEGFR2 expression was measured with the ImageJ software. g CD31-positive blood vessel number per field under × 200 magnification. h VEGFR2-positive blood vessel number per field under × 200 magnification. ∗P < 0.05 versus control, #P < 0.05 versus MPS group. Error bar represents SD. Each group consisted of 10 rats/20 femoral heads (N = 20)

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Stem Cell Research & Therapy

ISSN: 1757-6512