Fig. 7

dMSC-sEVs improved fibroblast senescence. a ROS generation in HG aged HDFs with or without dMSC-sEVs. The fluorescence intensity is expressed as arbitrary units (a.u.) (n = 5); scale bar = 100 μm. b SA-β-gal assay was performed on HDFs after being treated with different concentrations of dMSC-sEVs. SA-β-gal-staining cells were counted in five randomized fields. c The expression level of p21 and the quantification result. The results were normalized to GAPDH expression (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001