Table 1 Summary of clinical trials using dental pulp- derived cells
From: Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine
References | Registration ID | Condition | Study Design | Patients, test/control | Interventions | Follow-up | Outcomes | Risk of Bias Assessments | |
|---|---|---|---|---|---|---|---|---|---|
Test | Control | ||||||||
D’aquino et al. [15] | NR | Socket preservation | SM-CT | 17, 17/17 | DPSCs + collagen sponge | Collagen sponge | 3 months, 1 year | Radiography and clinical probing assessment revealed that optimal vertical repair and complete restoration of periodontal tissue were higher at the test site than the control site. | High |
Brunelli et al. [16] | NR | Sinus floor elevation | A case report | 1 | Pulp micro-grafts + collagen sponge | – | 4 months | Bone density in newly formed bone was about the double of native bone. | – |
Aimetti et al. [17] | NR | Periodontal diseases | A case report | 1 | Pulp micro-grafts + collagen sponge | – | 1 year | The defect was completely filled with bonelike tissue as confirmed through the reentry procedure. | – |
Nakashima et al. [18] | NR | Irreversible pulpitis | Case series | 5 | DPSCs + G-CSF + atelocollagen | – | 1, 2, 4, 12, 24 weeks | EPT demonstrated a robust positive response. MRI revealed that the regenerated tissue was similar to normal dental pulp. | – |
Ferrarotti et al. [19] | NCT03386877 | Periodontal diseases | RCT | 29, 15/14 | Pulp micro-grafts + collagen sponge | Collagen sponge | 6Â months, 12Â months | Clinical and radiographic parameters revealed that test sites exhibited significantly more PD reduction, CAL gain, and bone defect fill than controls. | Low |
Hernández-monjaraz et al. [20] | ISRCTN12831118 | Periodontal diseases | A case report | 1 | Allogeneic DPSCs from deciduous teeth + collagen sponge | – | 3 months, 6 months | The patient showed no sign of rejection and exhibited decreases in tooth mobility, PD and bone defect area. | – |
Barbier et al. [21] | EudraCTdatabase 2014-001913-18 | Socket preservation | SM-RCT | 32, 32/32 | Pulp micro-grafts + collagen matrix | Collagen matrix | 6Â months | No significant differences were found in the extent of bone repair during analyses of density or interdental septum height. | High |
Xuan et al. [22] | NCT01814436 | Dental pulp necrosis by trauma | RCT | 40, 30/10 | DPSCs aggregate from deciduous teeth | Apexification | 12Â months 24Â months | Test group showed significantly higher improvement of EPT, vascular formation, root length, and width of the apical foramen. | High |
Aimetti et al. [23] | NR | Periodontal diseases | Case series | 11 | Pulp micro-grafts + collagen sponge | – | 6 months, 12 months | PD, CAL, and radiographic intrabony defect were improved. | – |
NR [24] | NCT01932164 | Cleft lip and palate | Case series | 5 | DPSCs from deciduous teeth + collagen + hydroxyapatite biomaterial | – | 3 months, 6 months | Final completion of the alveolar defect with an 89.5% mean bone height was detected. | – |