Table 2 Summary of clinical trials using periodontal ligament (PDL)-derived cells
From: Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine
References | Registration ID | Condition | Study design | Patients (teeth), test/control | Interventions | Follow-up | Outcomes | Risk of bias assessments | |
|---|---|---|---|---|---|---|---|---|---|
Test | Control | ||||||||
Feng et al. [25] | NR | Periodontal diseases | Case series | 3 (16) | PDL progenitor + hydroxylapatite (Calcitite®) | – | 3, 6, 12, 26, 32, 42, 72 months | PPD and CAL were decreased and gingival recession was increased. | – |
Chen et al. 2016 [26] | NCT01357785 | Periodontal diseases | RCT | 30 (41), 20/21 | PDLSC sheets + DBBM (Bio-oss®) | Bio-oss® | 2 weeks, 3 months, 6 months, 1 year | No statistically significant differences were found for the increased CAL, PPD, or alveolar bone height between the test group and the control group. | Low |
Iwata et al. [27] | UMIN000005027 | Periodontal diseases | Case series | 10 (10) | PDL-derived cell sheet + beta-tricalcium phosphate (β-TCP) granules | – | 3 months, 6 months | PPD, CAL, and radiographic bone height were improved in all cases. | – |