Table 3 Summary of clinical trials using gingiva- derived cells
From: Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine
References | Registration ID | Condition | Study design | Patients (sites), test/control | Interventions | Follow-up | Outcomes | Risk of bias assessments | |
|---|---|---|---|---|---|---|---|---|---|
Test | Control | ||||||||
Pini Prato et al. [28] | NR | Gingival augmentation | A case report | 1 (1) | GF + benzyl ester of hyaluronic acid (HYAFF®) | – | 1 months, 2 months, 3 months | A fully keratinized tissue was regenerated. | – |
Pini Prato et al. [29] | NR | Gingival augmentation | Case series | 6 (7) | GF + benzyl ester of hyaluronic acid | – | 1 month, 3 months | An increased amount of gingiva was obtained, and the histological examination revealed a fully keratinized tissue on all the treated sites. | – |
Mohammadi et al. [30] | NR | Insufficient attached gingiva | SM-RCT | 9 (18), 9/9 | GF + bovine skin collagen type I | Periosteal fenestration technique | 3Â months | The difference between the width of keratinized gingiva in test and control sites was significant. | Some concerns |
Murata et al. [31] | NR | Gingival recessions | Case series | 4 (14) | GF + atelo-collagen + hyaluronic acid sponge | – | 13 to 40 weeks | The average root coverage and keratinized and attached gingival tissue were increased. | – |
Jhaveri et al. [32] | NR | Gingival recessions | SM-RCT | 10 (20), 10/10 | GF + acellular dermal matrix allograft | Subepithelial connective tissue graft | 3Â months, 6Â months | There were no significant differences between test and control sites for all measured clinical parameters. | Low |
Köseoğlu et al. [33] | NR | Gingival recessions | SM-RCT | 11 (22), 11/11 | GF + collagen membrane | Collagen membrane | 3 months, 6 months, 12 months | A statistically significant increase was detected in PRC in the test group compared with the control group. | Some concerns |
Milinkovic et al. [34] | NR | Gingival recessions | SM-RCT | 18 (48), 24/24 | GF + collagen matrix (BioGide®) | Connective tissue graft | 12 months | There was no statistically significant difference among groups regarding change in gingival recession coverage, CAL, and RES. | Some concerns |