Table 2 The role of MSI1 in promotion of different solid tumors
From: Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells
Type of cancer | Pathways | Function | Target genes | Regulation of MSI1 expression | Reference |
|---|---|---|---|---|---|
Glioblastoma multiform | Notch signaling | Proliferation of glioblastoma; tumorspheroids and neuronal differentiation | – | miR-34a, miR-101, miR-128, miR-137, miR-138 | Penalva, 2011 |
Glioblastoma multiform | Notch and PI3 Kinase/Akt Signaling | Cancer cell growth | Caspase3 | – | Okano, 2012 |
Glioblastoma multiform | Double-strand break repair and nonhomologous end-joining (NHEJ) | Radio-resistance | DNA-protein kinase catalytic subunit (DNA-PKcs) | – | Penalva, 2016 |
Glioblastoma multiform | AKT signaling and apoptosis | Malignancy and chemoresistance | Caspase3, cleaved PARP | – | Chen, 2016 |
Colorectal cancer | Wnt and Notch signaling | Cancer progression | Hes1, c-Myc, APC | miR-137 | Liang, 2015 |
Ovarian cancer | – | Tumor progression | p21, p27, and p53 | miR-761 | Zhang, 2016 |
Lung cancer | AKT signaling | Malignancy and Chemo resistance | pAKT | miR-181 | Xu, 2017 |
Cervical cancer | Cell cycle checkpoint | Tumor growth and cell proliferation | p21, p27 and p53 | – | Zheng, 2014 |
Breast cancer | Epithelial-mesenchymal transition | Epithelial-luminal cell state | Jagged1 | – | Burge, 2014 |