Fig. 6

Functional evaluation of hydrogel composites loaded with nanoparticles containing conditioned medium (MTT assay). a Relative cell viability (%) of MSCs seeded on hydrogel composite (normalized with 2D control), b relative cell viability (%) of HFFs seeded on hydrogel composite (normalized with 2D control), c relative cell viability (%) of MSCs treated with extracts (normalized with NC), and d relative cell viability (%) of HFFs treated with extracts (normalized with NC) (***p < 0.001, **p < 0.01, *p < 0.05). Abbreviations: ScCM-NP-H, serum-containing conditioned medium encapsulated in nanoparticles—embedded in hydrogel composite; SfCM-NP-H, serum-free conditioned medium encapsulated in nanoparticles—embedded in hydrogel composite. G1: 5% H extract; G2: 10% H extract; G3: 5% ScCM-NP-H extract; G4: 10% ScCM-NP-H extract; G5: 5% SfCM-NP-H extract; G6: 10% SfCM-NP-H extract; G7: DMEM+ 10% FBS