Table 4 Promising outcomes with preconditioning strategies on MSCs in preclinical kidney transplantation studies
Year | Animal | MSCs source | Preconditioning | Timing of infusion | Outcomes | References |
|---|---|---|---|---|---|---|
2013 | Rats | BM-MSCs | Gene modification | Day 1 | ↑CXCR4, ↑proliferative, secretory and migratory ability, ↑Tregs, ↓pathological scores, ↑graft renal function | Cao et al. [51] |
2018 | Rats | BM-MSCs | Incubation with trophic factors/cytokines | Day 0 | ↑CXCR4, ↑survival and migratory ability, ↓pathological scores, ↑graft renal function | Zhang et al. [52] |
2015 | Rabbits | BM-MSCs | Gene modification | Day 0 | ↑IDO, ↑Tregs, ↓T cells, ↓AR, ↑graft renal function and survival | He et al. [54] |
2016 | Rats | A-MSCs | Gene modification | Day − 4 | ↑OX40Ig, ↑Tregs, ↓AR, ↑graft renal function and survival | Liu et al. [56] |