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Table 1 HucMDEs relieve liver dysfunction and improve lipid profile in T2DM rats

From: RETRACTED ARTICLE: Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy

 

Control + PBS

T2DM + PBS

T2DM + HDEs

T2DM + HucMDEs

ALT (IU/l)

66.26 ± 5.10

100.62 ± 6.13**

103.71 ± 7.16

82.13 ± 6.13#

AST (IU/l)

195.23 ± 12.05

332.51 ± 16.58***

340.72 ± 18.45

293.05 ± 11.25#

TC (mmol/l)

1.95 ± 0.08

2.94 ± 0.14***

2.88 ± 0.15

2.16 ± 0.11##

TG (mmol/l)

0.78 ± 0.06

1.54 ± 0.08***

1.63 ± 0.10

1.23 ± 0.09#

  1. After STZ induction and HDEs, HucMDE treatment for another 2 months, rats were anesthetized with chloral hydrate. Blood was collected to measure the levels of liver function (ALT alanine aminotransferase, AST aspartate aminotransferase) and the levels of lipid (TC total cholesterol, TG triglyceride). Data were presented as mean ± SD (n = 7). *P < 0:05; **P < 0:01; ***P < 0.001 (compared with the control group), #P < 0:05; ##P < 0:01; ###P < 0.001 (compared with the T2DM + HDEs group)
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Stem Cell Research & Therapy

ISSN: 1757-6512