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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation

Fig. 5

The effects of sFgl2-MSCs on the polarization of macrophages in vivo. a The infiltration of iNOS+ (M1) and ARG-1+ (M2) macrophages in myocardial tissues was evaluated by IHC staining on day 7 in the CsA, WT-MSCs, MSCs-NC, and sFgl2-MSCs groups after heart transplantation. b, c Flow cytometry analysis of CD68, CD16/32, and CD206 expressions of splenocytes isolated from the spleen samples of recipient mice was performed on day 7 in all groups and on day 14 in the CsA, WT-MSCs, MSCs-NC, and sFgl2-MSCs groups. The data were reported as mean ± SD, n = 3. *Significant difference, P < 0.05; ***significant difference, P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512