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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway

Fig. 2

MT-Exo inhibited the inflammatory response by increasing the ratio of M2 polarization macrophages to M1 polarization in vitro. RAW264.7 cells were treated with PBS, LPS (100 ng/mL), LPS + Exo and LPS + MT-Exo for 24 h. ELISA was performed to detect the concentrations of a IL-1β, b TNF-α and c IL-10 from the supernatants. The relative gene expressions of d IL-1β, e TNF-α, f IL-10, g Arg-1 and h iNOS were detected (n = 3, *p < 0.05)

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Stem Cell Research & Therapy

ISSN: 1757-6512