Table 1 Overview of pre-clinical study details
Author (year) | Study design | Animal characteristics | Intervention characteristics | Outcome measures | ||||
|---|---|---|---|---|---|---|---|---|
Disease model | Species | Age | Immunosuppression | Cell type; source (origin) | Total dose (cells/kg), route, timing of delivery, frequency | Timing of assessment relative to injury | Ventricular function mode of assessment | |
Agarwal et al. [10] | RVHF | Crl:NIH-Foxn1rnu rats | 5–6 weeks | Athymic | Cardiac progenitor (xenogeneic) | 6.6 × 106; intramyocardial; 2 weeks; once | Two weeks and 1 month | Echo |
Albertario et al .[11] | RVHF | Landrace pigs | DNR | DNR | Thymic (xenogeneic) | 5.0 × 105 a; patch/graft; DNR; once | DNR | Echo, cardiac MRI |
Borenstein et al. | RVHF | Ile de France rams | 4 months | Dexamethasone | Skeletal muscle (autologous) | 4.3 × 105; intramyocardial; 3 h; once | Day 0 and day 60 | Cath |
Brizard et al. [12] | Cardiopulmonary bypass | Border-Leicester lamb | 5–7 days | DNR | Umbilical cord blood (xenogeneic) | 8.0 × 106; intracoronary; intraoperative; once | DNR | Cath |
Cao et al. | RVHF | New Zealand white rabbits | 1 month | DNR | Bone marrow (autologous) | 1.9 × 107; intravenous; 3 months; once | Two weeks | Echo, Cath |
Chery et al. | RVHF | RNU nude rats | DNR | DNR | Thymic (xenogeneic) | 1.8 × 107; cell sheet; 2 weeks; once | DNR | Echo |
Davies et al .[13] | RVHF | Leicester sheep | 10 days | Cyclosporine | Umbilical cord blood (xenogeneic) | 7.0 × 105; epicardial; 30 min; once | One month | Cath |
Henning et al. | DCM | TO2 hamsters | 1 month | DNR | Umbilical cord blood (xenogeneic) | 5.3 × 107; intramyocardial; 1 month; once | Monthly, 1 to 5 months | Echo |
Lambert et al. | RVHF | Landrace pigs | 2–3 months | Tacrolimus | Cardiac progenitor (xenogeneic) | 4.7 × 105; intramyocardial; 4 months; once | Four months and 7 months | Cath |
Liu et al. | RVHF | Wistar lamb | DNR | DNR | Adipose (autologous) | 5.0 × 107; intravenous; 3 months; once | DNR | Echo, Cath |
Nana-Leventaki et al .[14] | AI | Lewis rats | 5–6 weeks | DNR | Cardiosphere derived (autologous) | 1.7 × 106 b; intracoronary; 10 days; once | One day, 10 days, 1 month | Echo |
Schmuck et al. | RVHF | Sprague Dawley rats | 5–6 weeks | DNR | Cardiac fibroblasts (xenogeneic) | 2.0 × 106 a; bioscaffold implanted into RV; 3 weeks; once | Baseline, 3 weeks and 6 weeks | Echo, Cath |
Sugiura et al. (2016) | RVHF | Nude athymic rats | DNR | Athymic | Cardiac (xenogeneic) | 2.0 × 105 a; patch; DNR; once | Two and 4 months | Echo |
Trac et al. | RVHF | Crl:NIH-Foxn1rnu rats | 6 weeks | Athymic | Cardiac progenitor (xenogeneic) | 3.0 × 106; intramyocardial; 2 weeks; once | Weekly for 4 weeks | Echo |
Umar et al. (2009) | RVHF | Wistar rat | 8 weeks | DNR | Bone marrow-derived mesenchymal stem cells (autologous) | 4.4 × 103; intravenous; 2 weeks; once | Two weeks | Cath |
Wehman et al. (2016) | RVHF | Yorkshire swine | 2–3 weeks | Cyclosporine and methylprednisolone | Bone marrow (xenogeneic) | 1.25 × 105; intramyocardial; 30 min; once | Four months | Echo |
Wehman et al. (2017) | RVHF | Yorkshire swine | 2–3 weeks | Cyclosporine and methylprednisolone | Cardiac progenitor (xenogeneic) | 1.25 × 105; intramyocardial; morning of isolation; once | One day and 1 month | Echo |
Yerebakan et al. | RVHF | Domestic sheep | 4 months | DNR | Umbilical cord blood (autologous) | 2.0 × 106; intramyocardial; intraoperative; once | Six and 12 weeks | Echo, Cath |