Fig. 6

DLX5 and HOXC8 enhanced SCAP-mediated cartilage regeneration in rabbit knee models. a Macroscopic observation of cartilage defect healing. Scale bars, 1 mm. b HE staining results. Scale bars, 500 μm (B1–4), 200 μm (B5–8), and 100 μm (B9–12). (The black arrow shows the edge of the defect; B5–B8 is the partial enlargement of the red box in B1–B4; B9–B12 is the partial enlargement of the red box in B5–B8; the yellow dotted line shows the regenerated tissue at the defect site). c Toluidine Blue staining results. Scale bars, 500 μm. d Safranin-O staining results. Scale bars, 500 μm. e Alcian Blue staining results. Scale bars, 500 μm. f Immunohistochemical staining results of COL2. Scale bars, 500 μm. g Quantitative assessment of macroscopic results. h Quantitative assessment of histological results. One-way ANOVA analysis was performed to determine the statistical significance. All error bars represent s.d. (n = 6). **P ≤ 0.01