Fig. 2

Blood urea nitrogen (BUN), serum uric acid (UA) and serum creatinine (Scr) from different experimental groups. Rats were subjected to unilateral ureteral obstruction (UUO), followed by intravenous injection of young or old MSC-EVs (n = 5 each group). BUN (b), UA (d) and Scr (f) were detected at the beginning of the experiments and at an end point of 7 and 14 days after surgery. LVs-miR-294/133 mimic/inhibitors were injected into the tail vein of young/old rats in these groups 3 days before UUO surgery (n = 5 each group). BUN (a), UA (c) and Scr (e) were detected at the beginning of the experiments and at an end point of 7 and 14 days after surgery. *p < 0.05, **p < 0.01