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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Therapeutic effect of integrin-linked kinase gene-modified bone marrow-derived mesenchymal stem cells for streptozotocin-induced diabetic cystopathy in a rat model

Fig. 4

The dynamic changes of angiogenesis in the bladder tissue at different stages of the treatment. a–b Graphical representation of culture supernatant bFGF and SDF-1 concentrations determined by ELISA for each group in vitro. The concentration of bFGF and SDF-1 in the Ad-ILK-BMSC group was significantly higher (*P < 0.05) than those in the BMSCs and Ad-null-BMSC group. c The protein expression of CDH1 (one indicator of migration), VEGF-A (one indicator of angiogenesis), and vWF (one indicator of vascular endothelial cell marker) by western blot in the bladder wall of each group at different stages of the treatment. d The expression of CD31 (one indicator of vascular endothelial cell marker) by immunofluorescence staining in the bladder wall of each group at different stages of the treatment. e–g A statistical chart of the relative optical density of CDH1, VEGF-A, and vWF in each group. *P < 0.05 versus BMSCs and Ad-null BMSC group. h A statistical chart of the mean density of CD31 in each group. *P < 0.05 versus BMSCs and Ad-null BMSC group

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Stem Cell Research & Therapy

ISSN: 1757-6512