Fig. 5

Effect of MAPC-CM on the rate of excisional wound healing. Representative images of MAPC-CM treated and control wounds at days 3, 7 and 14 of healing (a). Analysis of images using Image Pro-Plus program demonstrates decreased macroscopic wound area in MAPC-CM-treated wounds on days 3, 7 and 14 post-injury (b). Representative images of MAPC-CM-treated and control wounds sections after H&E staining at days 3, 7 and 14 of healing. Images captured at 10× objective. Black dashed lines indicate wound width measured (c). The histological analysis of wounds demonstrates decreased microscopic wound area (d), wound width (e) and increased average re-epithelialisation (f) in MAPC-CM-treated wounds. n = 8. All data is represented as mean ± SEM. Statistical significance calculated by two-way ANOVA followed by Bonferroni post-tests, where * = p < 0.05, ** = p < 0.01, *** = p < 0.001, ns = non-significant