ID/concentration (pg/mL) | Description/function | |
---|---|---|
ECM proteins | Matrix metalloproteinase (MMP-1)/(29,838 ± 385) | Involved in collagen degradation, ECM remodelling cell migration [22] and angiogenesis [23]. |
Tissue inhibitor of metalloproteinase (TIMP-1)/(> 771,464) | Inhibitor of MMPs and regulator of cell migration [22]. | |
Growth factors and modulatory proteins | Hepatocyte growth factor (HGF)/(1817 ± 38) | Accelerates re-epithelialisation. Suppresses inflammation. Promote angiogenesis [24] |
Vascular endothelial growth factor (VEGF) (725 ± 42) | Proangiogenic mediator [25]. | |
Fibroblast growth factor-2 (FGF-2)/(172 ± 55) | Promotes proliferation and migration of fibroblasts and affect collagen deposition [26]. Contributes to the collagen maturation [27]. | |
Adhesion Molecules | Vascular cell adhesion protein (VCAM-1)/(32,641 ± 1538) | Cell adhesion molecule. Involves in inflammation, cell proliferation and migration [28]. |
CD166 (ALCAM)/(89,555 ± 955) | Regulator of T cells and MMP activity [29]. | |
CD44/(9344 ± 938) | Regulator of cell migration, survival and differentiation [30]. | |
Inflammatory cytokines | Monocyte Chemoattractant Protein-1 (MCP-1)/(17 ± 1) | Controls the migration and recruitment of monocytes/macrophages during inflammation [31]. |
Interleukins (IL): IL-8 (262 ± 110), IL-2 (21 ± 2), IL-1β (9 ± 0) | Pro-inflammatory cytokines [32]. | |
IL-6 (1150 ± 414) | A pro-inflammatory cytokine and an anti-inflammatory cytokine [33] |