Table 1 MAPC cell protein secretome. Functionally distinct classes of molecules identified by bead array assays

ECM proteins

Matrix metalloproteinase (MMP-1)/(29,838 ± 385)

Involved in collagen degradation, ECM remodelling cell migration [22] and angiogenesis [23].

Tissue inhibitor of metalloproteinase (TIMP-1)/(> 771,464)

Inhibitor of MMPs and regulator of cell migration [22].

Growth factors and modulatory proteins

Hepatocyte growth factor (HGF)/(1817 ± 38)

Accelerates re-epithelialisation. Suppresses inflammation. Promote angiogenesis [24]

Vascular endothelial growth factor (VEGF) (725 ± 42)

Proangiogenic mediator [25].

Fibroblast growth factor-2 (FGF-2)/(172 ± 55)

Promotes proliferation and migration of fibroblasts and affect collagen deposition [26]. Contributes to the collagen maturation [27].

Adhesion Molecules

Vascular cell adhesion protein (VCAM-1)/(32,641 ± 1538)

Cell adhesion molecule. Involves in inflammation, cell proliferation and migration [28].

CD166 (ALCAM)/(89,555 ± 955)

Regulator of T cells and MMP activity [29].

CD44/(9344 ± 938)

Regulator of cell migration, survival and differentiation [30].

Inflammatory cytokines

Monocyte Chemoattractant Protein-1 (MCP-1)/(17 ± 1)

Controls the migration and recruitment of monocytes/macrophages during inflammation [31].

Interleukins (IL): IL-8 (262 ± 110), IL-2 (21 ± 2), IL-1β (9 ± 0)

Pro-inflammatory cytokines [32].

IL-6 (1150 ± 414)

A pro-inflammatory cytokine and an anti-inflammatory cytokine [33]