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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT/eNOS pathway

Fig. 7

The inhibition of miR-221-3p suppressed ATV-Exos-mediated angiogenesis of HUVECs. a Ten candidate miRNAs were selected for qRT-PCR. b Cell proliferation of HUVEC treated by NCI, ATV-Exos+NCI, and ATV-Exos+221I for 1, 3, and 7 days. c The images of cell migration and tube formation of HUVEC treated with NCI, ATV-Exos+NCI, and ATV-Exos+221I. d Quantitative analysis of cell migration ability. e Quantitative analysis of tube formation ability. f The VEGF concentration of supernatant in HG medium supplemented with NCI, ATV-Exos+NCI, and ATV-Exos+221I through Elisa. g The relative expression levels of ANG1, PDGF, bFGF, and EGF of HUVEC treated with NCI, ATV-Exos+NCI, and ATV-Exos+221I examined by qRT-PCR. *P < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512