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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Involvement of miRNA203 in the proliferation of epidermal stem cells during the process of DM chronic wound healing through Wnt signal pathways

Fig. 2

Overexpression of miR-203 reduce the number of ESCs and impaired their proliferation capacity. K15+ and P63+ cell in normal rats and rats with type 2 diabetes wounded skin (a). mRNA expression of K15, P63, and Intergrin-β1 in normal rats and rats with type 2 diabetes wounded skin (b). Colony-forming assay for mannitol/glucose-incubated ESCs (c, d). Overexpression of miR-203reduce expression of K15, K19, P63, and Intergrin-β1 (e). Inhibition of miR-203 improve colony-forming assay for mannitol/glucose-incubated ESCs (f, g). Data are representative profile of clustered miRNA in individual samples and expressed as the mean ± SD of each group of samples from at least three separate experiments. *p < 0.05; **p < 0.01; ***p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512