Fig. 8

UC-MSC-CM or UC-MSC-Exo depressed cytokine expression in high glucose-injured HK2 cells. a-d mRNA expression of TGF-β (a), IL-6 (b), IL-1β (c) and TNF-α (d) in HK2 cells. e-h Concentration of TGF-β (e), IL-6 (f), IL-1β (g), and TNF-α (h) in the supernatant of HK2 cells. i Concentration of EGF, FGF, HGF, and VEGF in UC-MSC-CM and UC-MSC-Exo. N = 3 independent experiments. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01 vs LG group; ^#P < 0.05, ^##P < 0.01 vs HG group; ^★P < 0.05, ^★★P < 0.01 vs HK2-SM group, ^▽P < 0.05 vs hrGEC-SM group. UC-MSC-CM: UC-MSC conditioned medium; UC-MSC-Exo: UC-MSC-derived exosomes; LG: low glucose; HG: high glucose; SM: standard medium