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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Hypoxia alleviates dexamethasone-induced inhibition of angiogenesis in cocultures of HUVECs and rBMSCs via HIF-1α

Fig. 4

Dexamethasone suppressed HUVEC angiogenesis by upregulating the expression of TIMP-3. a Western blotting was performed to measure the expression of angiogenesis-related proteins at 72 h, and protein expression was quantified by ImageJ software. b TIMP-3 gene expression was effectively silenced by specific siRNA sequences. c A Matrigel tube assay was used to detect HUVEC angiogenesis after silencing TIMP-3 expression. d After TIMP-3 in HUVECs was silenced, Western blotting was performed to measure angiogenesis-related protein expression at 72 h. *p < 0.05, compared with HUVECs treated with the DEXA group. #p < 0.05, compared with HUVECs treated with siNC. ns: p > 0.05, there was no significant difference. n = 3

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Stem Cell Research & Therapy

ISSN: 1757-6512