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Table 1 Characteristics of included studies

From: Efficacy assessment of mesenchymal stem cell transplantation for burn wounds in animals: a systematic review

Author Year Region Total No. of wounds Species/strain Gender/weight(g) Age Model Cell type Dosage AD Timing (post burn)
MSC Con
Xue 2013 China 60 30 30 Mice/ICR M/NA 8–10 W Partial thickness (3–5% TBSA), 90 °C water for 3 s H-BMSCs 1 × 106 cells/wound Local injection Immediately
Karimi 2014 Iran 18 9 9 Mice/Balb/c M/40 NA Full thickness, a 96 °C needle for 8 s M-ADSCs 1 × 106 cells/wound Local injection Immediately
Loder 2015 USA 10 5 5 Mice/C57BL/6 M/NA 26–28 W Partial thickness (30% TBSA), 60 °C water for 17 s Syngenic M- ADSCs 1 × 106 cells/wound Local injection 24 h
Bliley 2016 USA 24 12 12 Mice/athymic nude F/NA 7–9 W Full thiness, a 70 °C brass stamp for 10s H-ADSCs 6.8 × 106 cells/wound Local injection 24 h
Shumakov 2003 Russian 30 20 10 Rat/Wistar M/(300–350) g Adult Full thiness (18–20% TBSA), a 97.7 °C metal plate for 8 s Auto/Allogenic R-BMSCs 2 × 106 cells/wound NA 48 h
Singer* 2013 USA 20 20 20 Rat/Sprague-Dawley M/(300–400) g NA Full thiness, a 100 °C brass comb for 30s R-BMSCs 1 × 106 cells/wound Tail vein 60 m
Liu 2014 China 84 42 42 Rat/Wistar M/(180–220) g 6 W Full thiness (30% TBSA), 94 °C water for 12 s H-UCMSCs 5 × 106 cells/wound Tail vein 72 h
Zhang 2015 China 84 42 42 Rat/Sprague-Dawley M/(200 ± 5) g NA Full thiness, burned iron for 25 s H-UCMSCs 2 × 106 cells/animal Local injection 24 h
Clover* 2015 Ireland 3 36 36 Pig/Landrace F/(25–30) kg NA Partial thickness (5% TBSA), a 80 °C brass block for 30 s Allogenic P-BMSCs 4.5 × 106 cells/wound Cover Immediately
Abbas 2018 Turkey 50 20 20 Rat/Wistar M/(300–325) g Adult Thickness unavailable, a 100 °C brass comb for 30 s R-BMSCs 1 × 106 cells/wound Local injection 30 m
Alapure 2018 New Orleans 8 4 4 Mice/C57BL/6 J F/NA 9 W Full thiness, a 100 °C alloy-aluminum-rod for 4 s M-BMSCs seeded AC gels 1 × 105 cells/wound Local injection 48 h
Banerjee 2019 USA 8 4 4 Rat/Harlan M/NA 8–10 W Partial thickness, a 87 °C brass for 10s R-ADSCs 5 × 104 cells/wound Local injection 9d
Chang* 2018 Taiwan 20 28 12 Rat/Wistar M/(176–250) g 6–7 W Full thiness (20% TBSA), a 95 °C metal rod R-ADSCs 5 × 106 cells/wound Local injection 24 h
Feng* 2019 Taiwan 6 9 9 Rat/Sprague-Dawley NA/(250–300) g NA Partial thickness, a 90 °C copper plate for 30 s R-ADSCs 5 × 105 cells/wound Local injection 30 m
Foubert* 2018 USA 15 16 14 Pig/Yorkshire swine F/(80–130) g 4-6 M Full thickness/Partial thickness (<10% TBSA), a 180–200 °C brass template for 30 s/60 s Autologous P-ADSCs 0.5 × 106 cells/kg Local injection 5 m
Kaita 2019 Japan 24 12 12 Mice/BALB/c Nude M/NA 6–8 W Full thickness, a 150 °C for 5 s H-ADSCs 5 × 104 cells/wound Local injection 1 h
Mahmood* 2018 Pakistan 12 12 12 Rat/Sprague-Dawley NA/NA 9–12 M Full thickness, a 100 °C brass rod (2x2cm) for 20s H-UCMSCs 3 × 104 cells/wound Cover 48 h
Oryan* 2019 Iran 8 16 16 Rat/Sprague-Dawley M/(200 ± 20)g 7–9 W Full thickness, a 100 °C aluminum bar for 10 s Allogenic R-ADSCs 1 × 106 cells/wound Local injection 48 h
Yang 2018 China 40 30 10 Mice/BALB/c M/F/NA Adult Full thickness, a 100 °C copper plate tip for 10 s H-UCMSCs 8 × 105 cells/wound Local injection 5 m
Liao 2019 China 72 24 24 Rat/Sprague-Dawley M/NA 8 W Partial thickness, 100 °C water M-ADSCs 2 × 106 cells/wound Cover NA
  1. USA United States of America, MSC mesenchymal stem cells, Con control, AD administration, TBSA total body surface area, H-BMSCs human bone marrow stem cells, M-ADSCs mouse adipose-derived mesenchymal stem cells, H-ADSCs human adipose-derived mesenchymal stem cells, R-BMSCs rat bone marrow stem cells, H-UCMSCs human umbilical cord mesenchymal stem cells, P-BMSCs pig bone marrow stem cells, M-BMSCs mouse bone marrow stem cells, R-ADSCs rat adipose-derived mesenchymal stem cells, P-ADSCs pig adipose-derived mesenchymal stem cells, W week, M month, M male, F female, NA not available, m minute, h hour, d day
  2. *Means there are more than one burn wounds in a rat, mouse, or pig