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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: A facile and scalable in production non-viral gene engineered mesenchymal stem cells for effective suppression of temozolomide-resistant (TMZR) glioblastoma growth

Fig. 6

Tumour suppression up to 36 days with repeated dosage of CD::UPRT::GFP_AD-MSCs/5FC. a When the tumour size reaches the ~ 100 mm3, 1 × 106 CD::UPRT::GFP_AD-MSCs or unmodified AD-MSCs were injected in the s.c tumour. All animals were treated with a daily dose of 500 mg/kg/day 5FC for 4 consecutive days starting 1 day post-MSC administration. The same cycle was repeated twice. b The tumour volume was measured every 3–5 days. Tumour volume (mm3) was calculated according to the standard formula of V = (W × W × L)/2. The line graph presents the average tumour volume + SD (n = 3). At the end of the experiment, mice were euthanized. c The tumours were extracted and fixed with 4% PFA. Images of tumours from each group are shown

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Stem Cell Research & Therapy

ISSN: 1757-6512