Fig. 7

The CHS/ADM scaffold promotes skin reconstruction. a The full-thickness wound. b Wound closure and corresponding wound closure percentages after control, MSCs-ADM, or MSCs-CHS/ADM scaffold treatment on days 7, 14, 21, and 28. c Statistical analysis of the wound closure rates in continuous time (7, 14, 21, and 28 days). (**p < 0.01, *p < 0.05, n = 6) d Representative images of Masson’s trichome staining of the control, MSCs-ADM, and MSCs-CHS/ADM scaffold groups on 7, 14, 21, and 28 days postwounding (n = 6). Scale bar, 200 μm. Inset is × 400. e Quantitative analysis of collagen regeneration, neovascularization and skin appendage regeneration on days 14 (**p < 0.01, *p <  0.05, n = 6). f Hematoxylin eosin (H&E) staining of the healing wounds in the control group, MSCs-ADM scaffold group, MSCs-CHS/ADM scaffold group, and normal group (healthy mouse skin) on postoperative day 28. Scale bar, 100 μm